Acute Ischemic Kidney Injury, Inflammation, and Mesenchymal Stem Cell Implantation

Mesenchymal stem cells (MSCs) migrate to sites of tissue injury and serve as an ideal vehicle for cellular gene transfer. This study investigated the potential of kallikrein-modified MSCs in healing injured kidney after acute ischemia.

Engrafted kallikrein-modified MSCs exhibited advanced protection against renal injury by reducing blood urea nitrogen, serum creatinine levels, and tubular injury. Their results indicate that implantation of kallikrein-modified MSCs in the kidney provides advanced benefits in protection against ischemia-induced kidney injury by suppression of apoptosis and inflammation.